If you’re talking tactical integration, it should happen outside this type of relationship at the USAFWC.
For administrative relationships: I’m all for the flattest organization possible, but in this particular case I don’t think the MAJCOM the right answer. Let’s be real: ISR is always going to be a red-headed stepchild in ACC. BUT ALSO! More important than being the center of attention, ISR needs to be responsive to the needs of ACC. (Why it makes sense to live there.) That said, having the 25th Air Force provides a balance. The two star has a seat at tables that ISR (now cyber and EA as well) wouldn’t otherwise occupy, and ACC can still make demands of their subordinate org in an absolute sense. (Rather than making it a MAJCOM/DRU unto itself.)
Now! If we really wanted to make a better structure, we’d dissolve the 480th ISRW and align its component parts with the collectors and customers. That, or suddenly pluck all WSOs up into their own wing with their own rules, own schedules, and admire why B-52s, B-1s, F-15Es, and the rest are suddenly not able to employ effectively. Ever shown up in the mission area an hour after takeoff only to discover that most of your airplane’s crew is out hiking 1,400 miles away?