People get too wrapped up about the pax/box issue. In 10+ years of airline flying, my "dealing with the pax," has amounted to a single divert for a heart attack (got more pay for that day) and kicking off one (1) drunk dude at the gate while still pushing on time. Even with that, homie don't do "dealing with pax." We have people who are specially trained to do that, so I have the FO call them out to "deal with the pax." Meanwhile, I'll be in the cockpit flipping through baseops.net, wondering how many minds have been changed on the abortion thread.
What really matters is how long it takes you to get from your home, to work and back. This single item will have the biggest impact of your QOL in an airline career. As an example, I'm typing away while drinking my morning coffee at 0500 (I've become my old man who can't sleep past 0500). Here in about an hour, I'll drive 55 minutes (about 60 miles) to the airport. I'll fly a 2-leg turn that is 2.2 hours of block. I'll block in before noon and be back in my car, headed home about 15 minutes later (Westin Valet will have my car waiting at the curb). If I don't stop at a squadron mates house for a beer, I should be home by 1300. I often bid reserve because I can sit short call from my house...hell I've flown my plane around on short call before (just stay ~500 feet to keep a cell signal). My days on long call are often spent flying my plane/hanging out at the hangar, tooling around the house, visiting family or drinking coffee/beer with current/former squadron mates who live within a mile or two of my house. Being able to do all of this, if infinitely more valuable than "not dealing with pax." So I'd recommend going to wherever allows you to do this the most.