I got my first jab yesterday at my local Pharmacy. I wanted the Pfizer flavor so I shopped around for one who stocked that one. 16 hours later, I haven't grown an extra testicle yet, so I suppose it's "so-far-so-good". Slightly sore arm... no other side-effects thus far, but I hear it's the 2nd one that gets you.
I found a good explanation about the COVID vaccines (cut and paste from an article):
Del Rio noted that the vaccines were specifically designed to protect against severe disease and death, and that's what those big vaccine trials looked for. "Infection was never an end-point in these studies," he said. That the vaccines were later found to prevent infection, he said "was a little bit ... like the cherry on the cake."
The phrasing also bothers immunologist and virologist Dr. Barney Graham, deputy director of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases, whose lab played a key role in the development of the Moderna vaccine.
Graham described it in a way that really made me visualize the vaccine's effect on your body.
"The vaccines were always designed to focus against disease in the lower airways [the lungs] -- not in the upper airways [the nose and upper throat]," he explained.
Think about that. According to Graham, a person becomes severely ill when the virus enters the lungs, and that is exactly where the vaccines offer up their most protective barrier. You see, the vaccines trigger the creation of immunoglobulins, which are proteins that function as antibodies. The main one generated by the vaccines is immunoglobulin G (IgG) which easily moves from the blood into the lower airways (the lungs) where it can block the virus. The level of IgG in blood needed to penetrate the tissues of the upper airways (the nose and throat) is much higher and that is why it is more difficult to block the virus from growing in the nose.
"That's why we see such consistency in the efficacy against severe disease. It wasn't designed to protect the upper airways as much," he explained.
It is also why Graham said scientists weren't expecting the vaccines to prevent infection as much. "We got very lucky that it did to some extent, against earlier strains," he added.
And, while the Delta variant is more transmissible, meaning more infections will certainly occur overall in both the vaccinated and unvaccinated, there will be a bigger difference between the two groups when it comes to protection against severe disease compared to protection against mild or asymptomatic illness, Graham explained. That's clear from data that show the overwhelming majority of hospitalizations and deaths happen in the unvaccinated, not the vaccinated.