This is a unique question to me due to having a lot of experience in the tanker world, -46 world, MAF, and aircrew training world. I'm also currently writing a dissertation for my doctoral program focusing on if automation is atrophying pilot aviating skill. My reaction is not that I don' think overall this is a bad situation to investigate, but that having non-test people do the first dry run of it as an extremely poor idea due to their lack overall lack of experience, especially for such a radical concept.
Huggy brought up that while he doesn't think the "mechanics of flying" of a -46 with one pilot is an issue, I'll add on to that. I don't think it's an issue if the single pilot has a lot of experience of flying. I'm sure we can agree that the commercial aviation and military worlds have vastly different definitions of what is considered an highly experienced pilot. In the MAF the highly experienced people are getting out to go to the airlines/cargo. That leaves very lightly to middle experience as the "highly experienced." The unique part of the -46 is that on the pilot side the program seemed to have pulled a lot of the shiny pennies from other MAF aircraft. We can all agree that the usual motivation for the shiny pennies to crossflow isn't to learn how to fly and eventually employ a new aircraft. It's to do staff job/get schools to get promoted. In my experience those PHOENIX products also weren't good pilots to begin with, now they're crossflowing to an aircraft they have to learn and will continue to be mediocre pilot until their PRFs are written and they get school/staff.
There's a thread on this forum that brings up good points about the changes at UPT/FTUs and how the quality of product is much less than it was 10-20 years ago. I agree and I don't blame the students, they're only there to learn and are a byproduct of their training. However, those byproducts are now AC/IPs in the -46, whom will probably be the ones tapped for this single pilot ops plan. We could probably also agree that flight training gives you a baseline of how to fly, but actually doing the flying and tactile learning is how you become experienced and good at it. Unfortunately, the MAF likes to shun those who want to be better aviators and rewards those who shirk flying to barely maintain currency.
In the -46 there are non-Edwards test units (there's a Test Ops Sq at McGuire for example), but the pilot I knew there just got out and he barely flew enough to only be a copilot in the -46. That's why it should go to Edwards. The test pilot and booms are extremely experienced, some of them helped early on designing the -46 during DT. They would be the SMEs to conduct this testing. I don't know how other MWS's are at Edwards, but the tanker folks came from line squadrons/taught at the FTUs, and have good mix of recency and experience in the MAF.
Like I said, I don't think it's a poor concept, but I think really experienced aviations need to DT/OT it first. Having a main operating base send a waiver up to the MAJCOM/CC to have their not as experienced aviators dry run it is a poor decision.