I propose a Foreign Exclusion Zone encompassing Syria, Iraq, Iran, Aghanistan, and Pakistan. It'll essentially be a regional cage match bounded by well armed countries that (more or less) have their shit together like Jordan, Israel, KSA, Oman, India, and the former USSR.
No one is allowed in or out of the FEZ. Then the Shia, Sunnis, Kurds, Pashtuns, Persians, Pakistanis et al sort it out. Sykes-Picot is out the window and the belligerents redraw their own borders. The extremists want to start suicide bombing? It's up to the local populace to crush their nuts. Pakistan wants to nuke everyone? Go for it, it's on them. Once the new borders reach some sort of equilibrium and show they can behave like 20th century nations, they are welcome back into the global community.