Whatever you choose for home defense I hope you practice with that weapon or "those weapons."
I keep all of my weapons secure so for immediate reaction I can roll out of bed on the floor and put either hand on a biometeric gun case. I keep two pistols in there, a Beretta M9 (I know I know....but I can drive nails with the M9 and shot expert everytime). I also have a Glock 19 with a couple of 30 round mags.
I picked the Glock because the 30 round mags are compatible with the Ruger PC charger which is 12 steps away in a closet safe. I also have the A300 and if the safe and if there is time I would prefer the A300 running slugs and 00 Buck. The A300 holds 8, I have another 7 on the gun and I keep a giant bandolier attached to the side of the safe that I can throw over my neck. On the range the A300 with 00 Buck is devastating out to 75', with slugs 300' is not out of the question but would not be my first choice for mid to long range.
If there is no time the PC Charger is in the stowed position so I can move fast, almost as fast as a pistol. I keep several mags with the Charger and have them situated so I can grab them in the dark. If I have time to take a side step the brace on the Charger folds out quick and it drives nails.
If I make it to my office and the big safe I have several choices but will likely grab one of several ARs with lights and red dots. Have a .44 Mag for dramatic effect and post fight taunting.