Baby steps.
For starters, let's get the FAA (and everyone else) to agree that it's ok when two pilots are flying, if one decides to take a nap, in the seat, at cruise... while the other pilot stays awake. Why is this such a big deal?
If we cannot get past that, then being OK " with fully RPS big jets doing cargo" is a long, long way from reality... and really shouldn't be discussed much until the former issue is solved.