Pretty damn significant
https://thedailyrecord.com/2024/03/26/bridge-collapse-likely-to-have-profound-impact-on-port-of-baltimore-operations/
The bridge was the only way for hazardous materials to get in and out of the city from what i've read also. Not allowed in the tunnels.
https://www.fleetowner.com/safety/article/21285334/how-baltimores-francis-scott-key-bridge-collapse-affects-truck-traffic-and-fleet-operations