I'm stationed here at Guam and love it. I admit it's not for everybody. So I'll offer some general advice and if you have specific questions, feel free to PM me.
I'm not in the det, but I'm familiar enough. Be prepared to be a bomber person (not just the MDS you're in now). Be proud of what experience you bring to the table, be honest about what you don't know, and be willing to learn. Keep in mind that the organization is new, so it's an interesting opportunity to shape the roles.
Keep in mind what the impacts will be to your career in regards to the potential of maybe not flying, being rated by a different chain of command than the rest of the base, etc. It might not make a diffference, but just be aware.
Family life is great so long as your honest with your spouse about what they're getting into. If you like big cities, lots of malls, and need to visit extended family often, you'll be in trouble. If you like any kind of water activity, hiking, or just enjoying the laid back feel of island life, it's awesome.
Island fever is a risk, but there's lots of opportunities to travel. Especially via space A.
Dont plan on getting a house on base since they're demoing most of the houses over the next couple years and rebuilding. Houses anywhere on island are small and basic. So leave the sweaters and unnecessary house clutter in storage before you PCS. Power outages are also common. Also understand that OHA is different than BAH (you don't pocket any leftover money).
Being stationed here is different than being TDY/deployed. For one, you're not living/working/eating/etc with the same house of dudes everyday for 6 months. If you were deployed here and thought "why haven't they fixed issue X with the mission after all these years", this is your chance to be the continuity and make things right.
Hope that helps.